Predictors of Development of Echocardiographic Left Ventricular Diastolic Dysfunction in the Subjects Aged 40 to 59 Years (from the Oulu Project Elucidating Risk of Atherosclerosis Study).
Identifieur interne : 000142 ( Main/Exploration ); précédent : 000141; suivant : 000143Predictors of Development of Echocardiographic Left Ventricular Diastolic Dysfunction in the Subjects Aged 40 to 59 Years (from the Oulu Project Elucidating Risk of Atherosclerosis Study).
Auteurs : Juha S. Perkiöm Ki [Finlande] ; Mikko Möttönen [Finlande] ; Jarmo Lumme [Finlande] ; Y Antero Kes Niemi [Finlande] ; Olavi Ukkola [Finlande] ; Heikki V. Huikuri [Finlande]Source :
- The American journal of cardiology ; 2015.
Descripteurs français
- Wicri :
- geographic : Finlande.
English descriptors
- KwdEn :
- Adult, Age Distribution, Atherosclerosis (diagnosis), Atherosclerosis (epidemiology), Atrial Natriuretic Factor (blood), Biomarkers (blood), Blood Glucose (metabolism), Blood Pressure, Body Height, Body Mass Index, Diabetes Complications (epidemiology), Diastole, Echocardiography (methods), Female, Finland (epidemiology), Follow-Up Studies, Glomerular Filtration Rate, Humans, Male, Middle Aged, Predictive Value of Tests, Prevalence, Prospective Studies, Risk Factors, Sensitivity and Specificity, Severity of Illness Index, Sex Distribution, Ventricular Dysfunction, Left (blood), Ventricular Dysfunction, Left (diagnosis), Ventricular Dysfunction, Left (epidemiology), Ventricular Dysfunction, Left (physiopathology).
- MESH :
- chemical , blood : Atrial Natriuretic Factor, Biomarkers.
- geographic , epidemiology : Finland.
- blood : Ventricular Dysfunction, Left.
- diagnosis : Atherosclerosis, Ventricular Dysfunction, Left.
- epidemiology : Atherosclerosis, Diabetes Complications, Ventricular Dysfunction, Left.
- chemical , metabolism : Blood Glucose.
- methods : Echocardiography.
- physiopathology : Ventricular Dysfunction, Left.
- Adult, Age Distribution, Blood Pressure, Body Height, Body Mass Index, Diastole, Female, Follow-Up Studies, Glomerular Filtration Rate, Humans, Male, Middle Aged, Predictive Value of Tests, Prevalence, Prospective Studies, Risk Factors, Sensitivity and Specificity, Severity of Illness Index, Sex Distribution.
Abstract
Factors in the middle age that are associated with the risk for development of diastolic dysfunction in long term are not fully established. The Oulu Project Elucidating Risk of Atherosclerosis OPERA study randomly selected middle-aged subjects with hypertension and age- and gender-matched control subjects (n = 1,045, age 51 ± 6 years, men 49.8%). After >20 years of follow-up, majority of the subjects still alive were available for reexaminations (n = 600). After excluding the subjects with mitral regurgitation, left ventricular ejection fraction <50%, and those from whom echocardiographic septal E/E' could not be reliably measured, the present analysis included 460 subjects. E/E' was divided into 3 subgroups (subgroup 1: E/E' ≤8, subgroup 2: 8 < E/E' < 15, subgroup 3: E/E' ≥15), subgroup 3 suggesting a significant diastolic dysfunction. Several baseline variables were associated with diastolic dysfunction: greater age (p = 0.001), female gender (p = 0.001), shorter height (p <0.001), larger body mass index (p = 0.008), greater systolic blood pressure (p = 0.001), greater pulse pressure (p <0.001), lower baroreflex sensitivity (p = 0.007), lower estimated glomerular filtration rate (p = 0.02), greater atrial natriuretic peptide (p = 0.001), greater fasting plasma glucose (p = 0.001), more common occurrence of diabetes (p = 0.011), and more common usage of antihypertensive medication (p = 0.001). After adjustments in the multivariate model, only systolic blood pressure (p = 0.001), shorter height (p = 0.002), and estimated glomerular filtration rate (p = 0.006) retained a significant association with the risk of developing diastolic dysfunction. In conclusion, greater systolic blood pressure, short height, and lower estimated glomerular filtration rate of the middle-aged subjects were the main determinants of development of diastolic dysfunction during a 20-year follow-up.
DOI: 10.1016/j.amjcard.2015.07.054
PubMed: 26341186
Affiliations:
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Electronic address: juha.perkiomaki@oulu.fi.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Mottonen, Mikko" sort="Mottonen, Mikko" uniqKey="Mottonen M" first="Mikko" last="Möttönen">Mikko Möttönen</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Lumme, Jarmo" sort="Lumme, Jarmo" uniqKey="Lumme J" first="Jarmo" last="Lumme">Jarmo Lumme</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Kes Niemi, Y Antero" sort="Kes Niemi, Y Antero" uniqKey="Kes Niemi Y" first="Y Antero" last="Kes Niemi">Y Antero Kes Niemi</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Ukkola, Olavi" sort="Ukkola, Olavi" uniqKey="Ukkola O" first="Olavi" last="Ukkola">Olavi Ukkola</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Huikuri, Heikki V" sort="Huikuri, Heikki V" uniqKey="Huikuri H" first="Heikki V" last="Huikuri">Heikki V. 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Perkiöm Ki</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland. Electronic address: juha.perkiomaki@oulu.fi.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Mottonen, Mikko" sort="Mottonen, Mikko" uniqKey="Mottonen M" first="Mikko" last="Möttönen">Mikko Möttönen</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Lumme, Jarmo" sort="Lumme, Jarmo" uniqKey="Lumme J" first="Jarmo" last="Lumme">Jarmo Lumme</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Kes Niemi, Y Antero" sort="Kes Niemi, Y Antero" uniqKey="Kes Niemi Y" first="Y Antero" last="Kes Niemi">Y Antero Kes Niemi</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Ukkola, Olavi" sort="Ukkola, Olavi" uniqKey="Ukkola O" first="Olavi" last="Ukkola">Olavi Ukkola</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Huikuri, Heikki V" sort="Huikuri, Heikki V" uniqKey="Huikuri H" first="Heikki V" last="Huikuri">Heikki V. Huikuri</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author></analytic><series><title level="j">The American journal of cardiology</title><idno type="e-ISSN">1879-1913</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age Distribution</term><term>Atherosclerosis (diagnosis)</term><term>Atherosclerosis (epidemiology)</term><term>Atrial Natriuretic Factor (blood)</term><term>Biomarkers (blood)</term><term>Blood Glucose (metabolism)</term><term>Blood Pressure</term><term>Body Height</term><term>Body Mass Index</term><term>Diabetes Complications (epidemiology)</term><term>Diastole</term><term>Echocardiography (methods)</term><term>Female</term><term>Finland (epidemiology)</term><term>Follow-Up Studies</term><term>Glomerular Filtration Rate</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Prevalence</term><term>Prospective Studies</term><term>Risk Factors</term><term>Sensitivity and Specificity</term><term>Severity of Illness Index</term><term>Sex Distribution</term><term>Ventricular Dysfunction, Left (blood)</term><term>Ventricular Dysfunction, Left (diagnosis)</term><term>Ventricular Dysfunction, Left (epidemiology)</term><term>Ventricular Dysfunction, Left (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Atrial Natriuretic Factor</term><term>Biomarkers</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Finland</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Ventricular Dysfunction, Left</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Atherosclerosis</term><term>Ventricular Dysfunction, Left</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Atherosclerosis</term><term>Diabetes Complications</term><term>Ventricular Dysfunction, Left</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Blood Glucose</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Echocardiography</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Ventricular Dysfunction, Left</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Distribution</term><term>Blood Pressure</term><term>Body Height</term><term>Body Mass Index</term><term>Diastole</term><term>Female</term><term>Follow-Up Studies</term><term>Glomerular Filtration Rate</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Prevalence</term><term>Prospective Studies</term><term>Risk Factors</term><term>Sensitivity and Specificity</term><term>Severity of Illness Index</term><term>Sex Distribution</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Finlande</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Factors in the middle age that are associated with the risk for development of diastolic dysfunction in long term are not fully established. The Oulu Project Elucidating Risk of Atherosclerosis OPERA study randomly selected middle-aged subjects with hypertension and age- and gender-matched control subjects (n = 1,045, age 51 ± 6 years, men 49.8%). After >20 years of follow-up, majority of the subjects still alive were available for reexaminations (n = 600). After excluding the subjects with mitral regurgitation, left ventricular ejection fraction <50%, and those from whom echocardiographic septal E/E' could not be reliably measured, the present analysis included 460 subjects. E/E' was divided into 3 subgroups (subgroup 1: E/E' ≤8, subgroup 2: 8 < E/E' < 15, subgroup 3: E/E' ≥15), subgroup 3 suggesting a significant diastolic dysfunction. Several baseline variables were associated with diastolic dysfunction: greater age (p = 0.001), female gender (p = 0.001), shorter height (p <0.001), larger body mass index (p = 0.008), greater systolic blood pressure (p = 0.001), greater pulse pressure (p <0.001), lower baroreflex sensitivity (p = 0.007), lower estimated glomerular filtration rate (p = 0.02), greater atrial natriuretic peptide (p = 0.001), greater fasting plasma glucose (p = 0.001), more common occurrence of diabetes (p = 0.011), and more common usage of antihypertensive medication (p = 0.001). After adjustments in the multivariate model, only systolic blood pressure (p = 0.001), shorter height (p = 0.002), and estimated glomerular filtration rate (p = 0.006) retained a significant association with the risk of developing diastolic dysfunction. In conclusion, greater systolic blood pressure, short height, and lower estimated glomerular filtration rate of the middle-aged subjects were the main determinants of development of diastolic dysfunction during a 20-year follow-up.</div></front></TEI><affiliations><list><country><li>Finlande</li></country></list><tree><country name="Finlande"><noRegion><name sortKey="Perkiom Ki, Juha S" sort="Perkiom Ki, Juha S" uniqKey="Perkiom Ki J" first="Juha S" last="Perkiöm Ki">Juha S. Perkiöm Ki</name></noRegion><name sortKey="Huikuri, Heikki V" sort="Huikuri, Heikki V" uniqKey="Huikuri H" first="Heikki V" last="Huikuri">Heikki V. Huikuri</name><name sortKey="Kes Niemi, Y Antero" sort="Kes Niemi, Y Antero" uniqKey="Kes Niemi Y" first="Y Antero" last="Kes Niemi">Y Antero Kes Niemi</name><name sortKey="Lumme, Jarmo" sort="Lumme, Jarmo" uniqKey="Lumme J" first="Jarmo" last="Lumme">Jarmo Lumme</name><name sortKey="Mottonen, Mikko" sort="Mottonen, Mikko" uniqKey="Mottonen M" first="Mikko" last="Möttönen">Mikko Möttönen</name><name sortKey="Ukkola, Olavi" sort="Ukkola, Olavi" uniqKey="Ukkola O" first="Olavi" last="Ukkola">Olavi Ukkola</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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